BANKPEPTIDE STAPLES PEPTIDE
The synthesis difference between stapled peptide and the normal linear peptide lies in being introduced the two non natural amino acids containing a-methyl and a-alkenyl in the process of solid phase synthesis.Then the two non natural amino acids occur olefin metathesis cyclization to form stable a-helix conformation of the carbon to synthesize stapled peptide.
Below,the red coloring depicts a peptide with helix, and the green coloring mean the hydrocarbon staple. Rendering based on PDB 4MZK.
A stapled peptides with multiple, tandem staples are sometimes referred to as stitched peptides Peptide staple is used to enhance pharmacologic performance of peptides.
The synthetic route of stapled peptide ：
Bankpeptide always adheres to the customer first business philosophy. Through accumulation of long years experiment, constantly optimization of the synthesis conditions and the purification technology, we already have a mature method of stapled peptide synthesis to provide highquality stapled peptides fully meeting the needs of customers in different kinds of research and development area.
DOCUMENT AND PACKAGING
Each peptide is shipped with a Document of HPLC and MS data for free. Other test datas can also be provided according to customer demand . Peptides are packed with ice bag and desiccants during shipment and storage. After opening, we recommend peptides are stored dry in a freezer (details given in our technical guide to handling peptides; a copy is shipped with each peptide).
a.What is the minimum quantity for a peptide?
The minimun for one peptide should be 1mg, and there is no maximum quantity for a peptide at Bankpeptide.
b.Which kind of solvent should I use?
According to your needs, the peptides can often dissolved in water, DMF,DMSO, and PBS Buffer.
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"Phase 1 Safety Study of ALRN-5281 in Healthy Subjects". ClinicalTrials. U.S. National Institutes of
Health. Retrieved 23 July 2015.
Chu, Qian; Moellering, Raymond E.; Hilinski, Gerard J.; Kim, Young-Woo; Grossmann, Tom N.; Yeh,Johann
es T.-H.; Verdine, Gregory L. (2015). "Towards understanding cell penetration by stapled peptides". Med.
Chem. Commun. 6 (1): 111–119.
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Bankpeptide biological technology co.,LTD(short for: Bankpeptide) was founded in 2014,which is a national high-tech enterprise engaging in the research ,development...
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